Synthesis and Chemiexcitation of a Distinct Chemiluminescent Luminophore based on a Curcumin Scaffold

Natural fluorogenic dyes are composed of unique molecular structures that could be harnessed for the design new chemiluminescent luminophores. Here we demonstrated how to simply transform an emissive curcumin scaffold into a novel luminophore. An appropriate bromo-curcumin intermediate was synthesized as substrate Stille cross-coupling reaction with adamantyl-stannane reagent. This late-stage functionalization afforded in one step enolether precursor can then oxidized singlet oxygen produce dioxetane luminophore produced intense light signal emission spectrum correlates its scaffold. is first example based on nature structure. We expect method described herein would useful synthesis luminophores by transforming other known precursors via approach.